Mirjam Nastasi was born in Utrecht, the Netherlands. She studied flute with Adriaan Bonsel, Nikolaus Delius and Aurèle Nicolet and musicology in Utrecht and Freiburg, Germany.

Nastasi initially focused on contemporary music, performing with various new music ensembles. Later on she took deep interest in early music and the trensverse flute, playing with musicians such as Frans Vester and others. On the transverse flute, she performed premiere recordings of solo concerti by Leopold Mozart, Johann Adolph Hasse and Pietro Nardini for SWR Radio. Nastasi played with several pianists and with numerous chamber ensembles such as Consortium Classicum. She also played in duo-formation with Sonja Prunnbauer (guitar) and Kirsten Ecke (harp) and at music festivals such as Frankfurt Feste and the Orlando Festival.

Mirjam Nastasi regularly holds chamber music courses at the International Chamber Music Academy Frenswegen and masterclasses in Gdansk, Krakow and at the European Academy of Music and Drama Montepulciano. She has been a regular jury member at competitions in Bayreuth, Krakow and Markneukirchen.

Nastasi has published on the topics of performance practice and musical rhetoric and taught classes on these subjects at the music conservatories of Freiburg, Bremen, Karlsruhe and Frankfurt.

At the age of 24, Nastasi became a flute teacher at the Koninklijk Conservatorium voor Muziek in The Hague. She later taught at the Music Conservatory in Frankfurt and at the University of Mainz. In 1991 she became professor for flute and methodology at the University of Music Freiburg. Between 1996 and 2006 she held the post of principal at this well-known University.

Nastasi is a contributor to the Flute Library and has worked for music publishers Broekmans & van Poppel in Amsterdam and for Universal Edition in Vienna. She is the editor of DIE SOLOFLÖTE, a collection published by Edition Peters in Frankfurt.